VG70 Invasive Ventilator

VG70 Invasive Ventilator

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Invasive mechanical ventilation can become a lifesaving intervention for your patients with respiratory and breathing difficulties. n95 mask near meThe term “invasive” is used if it involves any instrument penetrating via the mouth (such as an endotracheal tube), nose, or the skin (such as a tracheostomy tube through a stoma, n95 mask cvsa surgically-created hole in the windpipe) to serve as an artificial airway.1

The objectives of mechanical ventilation are primarily to provide oxygen, infrared thermometer lowesremove carbon dioxide, decrease the work of breathing and reverse life-threatening conditions such as hypoxemia, infrared thermometer home depotor insufficient oxygenation of arterial blood, and acute progressive respiratory acidosis, or build-up of carbon dioxide in the blood.1

There are two tubes used for invasive mechanical ventilation:

  • Standard endotracheal tube (ET) – inserted via the nose or mouth, the standard ET provides a secure airway when the balloon on the cuff is inflated and sealed, n95 mask walgreensand is mostly used in adult patients with acute respiratory failure; pediatric patients can benefit from uncuffed ET.2
  • Tracheostomy tube –inserted via a stoma, a surgically-created opening in the trachea, the tracheostomy tube is used for patients who need long-term mechanical ventilation, and exists with cuffed and uncuffed options; face masks n95 respiratorcuffed tracheostomy tubes seals the airway to control mechanical ventilation, while deflated cuffs or cuffless tubes may be introduced when the patient is more stable.

Invasive ventilation may be used during acute respiratory failure, weaning and for chronic respiratory failure when non-invasive ventilation is impossible to manage correctly. It can also be used as a means to maintain a patient’s airway during a surgical procedure, such as intubation done in the ICU.

Whether it is used in a hospital setting or at home (Home Mechanical Ventilation), invasive mechanical ventilation is paired with ventilation technology that continuously facilitates oxygen exchange/carbon dioxide exchange.3 At ResMed, we provide machines with several modes that use the latest technology for the most comfortable and effective therapy. Discover our range of ventilators for invasive mechanical ventilation.

Ventilation via Tracheostomy

Invasive ventilation via tracheostomy is typically used in infants and children with parenchymal lung or congenital heart disease. In addition it is used in young children who require continuous mechanical ventilation, those with severe craniofacial malformations (or other causes of upper airway or central airway obstruction that cannot be corrected by NIV) and those with severe developmental delay.3,8,104 Whenever possible, relatively small tracheostomy tubes are used to allow for a leak35,105: this facilitates speech and avoids damage to the tracheal wall. When leak around the tracheostomy tube is large, however, effective mechanical ventilation can be compromised.

This is especially true if the child is being ventilated in a volume-control mode, since the large leak will prevent adequate development of intrathoracic pressure to expand the chest because the ventilator breath escapes through the mouth and nose. 3m n95 respirator maskThe leak may be variable, so that even when mechanical ventilation is adequate during awake hours, significant hypoventilation can occur during sleep.106 This is remedied either by changing to a pressure-control mode of ventilation or by using a cuffed tracheostomy tube.

The presence of a tracheostomy increases the complexity of care for most patients requiring ventilatory assistance. 3m n95 respirator maskCaregivers must be taught how to suction, clean and change the tracheostomy tube and how to assess for displacement and obstruction.105 The presence of a tracheostomy tube interferes with the child’s speech and swallowing, 3m face mask n95increases risk for infection and aspiration and is associated with airway complications such as infection at the stoma site,

granuloma formation, tracheal stenosis and traumatic tracheoinnominate or tracheoesophageal fistula formation.107–109 Although the presence of a tracheostomy alone can increase caregiver stress,110 in some situations (such as the need for continuous ventilatory assistance and difficulty with secretion management in a young child) it can ease the burden of care. Thus the decision to advance from noninvasive to invasive ventilation must be individualized, considering the impact on both the child and the child’s caregivers.

Weaning from Mechanical Ventilation

Guilherme Sant’Anna MD, PhD, FRCPC, Martin Keszler MD, FAAP, in Assisted Ventilation of the Neonate (Sixth Edition), 2017


Weaning from invasive ventilation and subsequent extubation continue to be challenging problems in urgent need of further study. n95 mask cvsAvailable evidence indicates that early extubation is desirable, but our ability to predict the level of support at which this can be accomplished safely remains limited, especially in very preterm infants. There is strong evidence that volume-targeted ventilation accelerates weaning from MV.

There is also strong support for the use of caffeine and distending airway pressure following extubation. Evidence for other adjuncts to weaning and extubation is less well established. Improved tools for predicting successful extubation in this vulnerable population are currently being explored with the goal of reducing extubation failure and need for subsequent reintubation.


Invasive ventilation is indicated for patients who are not suited for NPPV or who fail NPPV (see following discussion). infrared thermometer lowesThe need for invasive mechanical ventilation may be an ominous sign. Patients with acute exacerbation of COPD requiring invasive mechanical ventilation have a higher ICU mortality and in-hospital mortality compared with nonventilated patients.227

Initial Approach and Maintenance

Ventilation Modes

Mechanical ventilation of COPD should lead to a significant decrease in excessive respiratory work. infrared thermometer home depotPatient-triggered ventilation modes, either assist-control or synchronized intermittent mandatory ventilation, typically accomplish this goal. Special care must be taken, however, because if these modes are not adequately adjusted to fit the characteristics of the patient, an increase in respiratory work results.228

PSV has been extensively used and reviewed in the literature.229,230 In COPD patients, PSV has been shown to decrease inspiratory effort as the applied pressure is increased; however, the response among patients varied significantly.231 At higher levels of support pressure, many patients show an activation of the respiratory muscles during the late phase of inflation, with the potential to produce ventilation dyssynchrony.

n95 mask walgreensThis may be more common in patients with longer time constants and patients who require higher inspiratory flows delivered for longer periods.228 We recommend that ventilation be provided as total support during the initial phase of respiratory management (assist-control volume ventilation or high-level PSV).

Inspired Oxygen

The goal of oxygenation should be to maintain an oxyhemoglobin saturation of at least 90% to 92%. face masks n95 respiratorIn dark-skinned patients, pulse oximetry may overestimate oxyhemoglobin saturation, and in these patients, we recommend targeting pulse oximetry values of 95% to ensure adequate oxygenation.232 Although there is no clear-cut clinical evidence that allows determination of the Fio2 threshold of concern for oxygen toxicity, based on animal studies of oxygen toxicity in normal lungs, attempts to lower Fio2 to 0.6 or less by the end of the first 24 hours of mechanical ventilation is a reasonable goal.233

Intrinsic Positive End-Expiratory Pressure

Before discussing ventilation settings in COPD complicated with ARF, a discussion of intrinsic PEEP (auto-PEEP, dynamic hyperinflation) is in order. Intrinsic PEEP occurs in the presence of insufficient exhalation times. coronavirus in usaThe respiratory system is prevented from returning to its resting state at the end of the expiration. Auto-PEEP, or intrinsic PEEP, is the positive difference between alveolar pressure and airway pressure at the end of expiration minus extrinsic positive pressures (PEEP or continuous positive airway pressure).

When mechanical ventilation induces hyperinflation, alveolar pressure remains continually positive during both phases of the respiratory cycle. If the next inspiration is held at the end of expiration, expiratory flow continues.

Intrinsic PEEP is typically not detected on the pressure gauge of the ventilator because it is open to the atmosphere except for a very brief moment at the end of expiration. n95 mask near meIf the expiration port of the circuit is occluded at end expiration in a relaxed patient with a delay of next inspiration, the pressure inside the lungs and in the circuit begins to equilibrate; if occlusion is sufficiently prolonged, intrinsic PEEP may be recorded.234

Auto-PEEP has numerous hemodynamic and mechanical consequences. When auto-PEEP is profound, barotrauma may occur. Hemodynamic consequences of auto-PEEP effect are more common with decreased venous return, decreased stroke volume, and hypotension. how a ventilator works, Auto-PEEP also increases respiratory work. This is represented by an increase of workload during spontaneous inspiration and by a depression in the sensitivity of ventilator triggering. Auto-PEEP is treated by decreasing inspiration time and increasing expiratory time. This is best done by decreasing rate and tidal volume.


The setting of the optimal triggering threshold is more difficult in COPD patients, especially if dynamic lung hyperinflation (intrinsic PEEP, auto-PEEP) exists. This is because the patient needs to generate a negative pressure equal to intrinsic PEEP before interfacing with the preset sensitivity on the ventilator. When auto-PEEP is high, the patient may exert significant inspiratory effort before the triggering threshold is reached, another cause of dyssynchrony.

china coronavirusIf the sensitivity of the ventilator has been placed at a very sensitive level, the ventilator may cycle inappropriately and can cause serious respiratory alkalosis, especially in the absence of significant auto-PEEP.

Many ventilators have flow-triggered options, and although theoretically flow triggering may reduce patient effort, more recent reports fail to show differences when flow triggering is compared with newer pressure-triggering devices, even in COPD patients, although it is known that flow-triggered ventilators work better when the patient has elevated requirements of inspiratory flow.235,236

Inspiratory Flow Rate

High inspiratory flow rates help satisfy the demands of most dyspneic or tachypneic COPD patients; it decreases the likelihood of dynamic hyperinflation and intrinsic PEEP. This decreases inspiratory time and increases expiratory time, minimizing auto-PEEP. coronavirus newsAn improvement in gas exchange has been found when inspiratory flows were increased from 40 to 60 L/min in COPD patients.237

Tidal Volume

In patients with known or suspected auto-PEEP, smaller tidal volumes (6 to 8 mL/kg) may be necessary to prevent alveolar overdistention, dynamic hyperinflation, and barotrauma.

Respiratory Rate

In the presence of auto-PEEP or a strong predisposition for auto-PEEP, elevations in respiratory rate must be avoided because expiratory time would be significantly decreased. Although synchronized intermittent mandatory ventilation with low spontaneous tidal volume may control minute ventilation, it has variable effects on auto-PEEP and may increase respiratory workload significantly. coronavirus cureFor these reasons, controlled mechanical ventilation with heavy sedation or sedation/paralysis may be the optimal approach.

Positive End-Expiratory Pressure

In the past, PEEP was avoided in patients with COPD because of the concern of worsening dynamic hyperinflation. coronavirus californiaNow it is known that application of extrinsic PEEP slightly lower than intrinsic PEEP may facilitate ventilator triggering because alveolar pressure now needs to be decreased to only below the level of the external PEEP, instead of below the level of atmospheric pressure, decreasing the work required to trigger the inspiration.238,239


In general, restoration of respiratory muscle function requires approximately 24 to 48 hours of mechanical ventilation.240–242 Before weaning COPD patients from mechanical ventilation, the premorbid condition that triggered ARF should be corrected, and an adequate neuromuscular competency-to-workload ratio should be achieved. where to buy n95 masks near meThe strategy for facilitating weaning from the ventilator should include an increase in inspiratory force and a decrease in the load on the respiratory system. See Chapter 44 for a comparison of various weaning techniques.

Extubation with Noninvasive Ventilation

In certain patient populations, the use of NPPV as a bridge to successful weaning is advocated. 3m face mask n95Extubation is immediately followed with institution of NPPV, and NPPV is subsequently weaned.  There is evidence that in selected patients, however, the use of NPPV could delay reintu-bation, and this delay was associated with increased mortality.243

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